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Dr. Bruce E. Elliott, B.Sc., M.Sc., Ph.D., Professor E-Mail (elliottb@post.queensu.ca) Room A307 Botterell Hall Telephone: (613) 533-2825 Facsimile: (613) 533-6830

Cross Appointments Professor of Pathology and of Oncology

Research Interests Regulation of tissue mesenchyme interactions in tumor growth and metastasis Targeting scatter factor/HGF autocrine loops in breast and lung cancer Role of cell adhesion-based signalling in tumor metastasis Immunotherapy of cancer metastasis

Details of Research Interests Studies on the Cellular and Molecular Biology of Breast Cancer Metastasis: The focus of Dr. Elliott's research is the role of scatter factor/HGF autocrine loops, and cell adhesion-based signalling cascades in the development of invasive breast cancer. Our approaches involve mutational and structure/function analysis, as well as the development of ligand/receptor antagonists. Animal models are also being used to test specific inhibitors for possible therapeutic intervention in breast cancer metastasis. He co-ordinates the Flow Cytometry and Confocal Microscope Multi-user Facility at Queen's University.

Selected Publications Saulnier, B. Bhardwaj, J. Klassen, D. Leopold, N. Rahimi, E. Tremblay, D. Mosher and B. Elliott. Fibronectin fibrils and growth factors stimulate anchorage-independent growth of a murine mammary carcinoma. R. Exp. Cell Res. 222:360-369, 1996 Rahimi, N., E. Tremblay and B. Elliott. Phosphatidylinositol 3-kinase activity is required for hepatocyte growth factor-induced mitogenic signals in epithelial cells. J. Biol. Chem. 271:24850-24855, 1996 Rahimi, N., W. Hung, E. Tremblay, R. Saulnier, and B. Elliott. c-SRC kinase activity is required for HGF-induced motility and anchorage-independent growth of mammary carcinoma cells. J. Biol. Chem. 273(50):33714-33721, 1998 Qiao H., Saulnier R., Patryzkat A., Rahimi N., Raptis L., Rossiter J., Tremblay E., Elliott B. Co-operative effect of hepatocyte growth factor and fibronectin in anchorage-independent cell survival of mammary carcinoma cells: Requirement for phosphatidylinositol 3-kinase activity. Cell Growth Differ. 11:123-33, 1999 Tuck, A.B.,   Elliott, B.E., Hota, C. Tremblay, E., and A.F. Chambers. Osteopontin-induced, integrin-dependent migration of human mammary epithelial cells involves activation of the hepatocyte growth factor receptor (Met). J. Cell. Biochem. 78:465-475, 2000 Hung, W. and Elliott, B.E. c-Src kinase activity is required for expression of hepatocyte growth factor in breast carcinoma cells. J Biol.Chem. Dec, 2000. (On line at JBC.org) Rahimi, N., Saulnier, R., Nakamura, T., Park, M., and B.E. Elliott. Role of hepatocyte growth factor in breast cancer: A novel mitogenic factor secreted by adipocytes. DNA Cell Biol. 13:1189-1197, 1994 Tuck, A.B., Park, M., Sterns, E.E., Boag, A., and B.E. Elliott. Co-expression of hepatocyte growth factor and receptor (Met) in human breast carcinoma. Am. J. Pathol. 148:225-232, 1996 Rahimi, N., Tremblay, E., McAdam, L., Park, M., Schwall, R. and B. Elliott. Identification of a hepatocyte growth factor autocrine loop in a murine mammary carcinoma.  Cell Growth Differ. 7:263-270, 1996 Elliott, B.E., Ekblom, P., Pross, H., Niemann, A. and K. Rubin. Anti-beta 1 integrin IgG inhibits pulmonary macrometastases and the size of micrometastases from a murine mammary carcinoma. Cell Adhes. Commun. 1:319-332, 1994

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Department of Microbiology & Immunology - Room 813, Botterell Hall
Stuart St., Kingston, ON, Canada, K7L 3N6
tel: (613) 533-2450 fax: (613) 533-6796